THE FREQUENCY OF RESISTANCE TO ANTIFUNGAL DRUGS IN CANDIDA ALBICANS ISOLATES ISOLATED FROM CASES OF VAGINITIS IN TABRIZ ALZAHRA HOSPITAL

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

MEDISM19_217

تاریخ نمایه سازی: 13 مهر 1397

Abstract:

Background and Aim:Gardenerlla vaginalis, Tricomonas vaginalis and Candida species especially Candida albicans consider as major causes of vaginitis.There are three classes of antifungal drug used for treatment of candidiasis: Azoles, Polyenes and Echinocandin. : Azoles, Polyenes , and Echinocandin. The occurrence of resisdence to antifungal drug is a major problem in treatment of vaginits. Therefore study was aimed to determine the prevalence of resistance to antifungal drugs, especially fluconazole in Candida albicans strains isolated from hospital Alzahra Tabriz.Methods:Isolates identification was done by direct microscopic exam(wet mount) cultivated in sabouraud dextrose agar medium. Diffreatiation betwen candida species was done by chrom Agar medium and Germ tube test and chlamidia conidi performed.Results:104 of 140 sampels were identified as candida albicans.Antibiotic resistance to fluconazol detected in 24 isolates.Antibiotic resisrance to amphotericin B identified 6 isolates.1 sampele finded resistance to nystatin.Resistance to ketoconazol diagnosed in 72 isolates and 72 sampel detected resistance to itraconasol.Conclusion:Due to incresed antibiotic resistance in candida albicans strain,Antibogram befor started the treatment in neccessery.

Keywords:

Candida albicans , Resistance to antifungal draugs , Vaginitis

Authors

Leila Mohammadi

Department Of Microbiology-Tabriz Rab Rashid Higher Education Institute

Mehdi Ghiami rad

Department Of Microbiology- Faculty Of Science- Islamic Azad University Ahar Brench – Ahar- Iran

Mehrdad Asadi

Department Of Microbiology- Faculty Of Medical - Islamic Azad University Tabriz Brebch – Tabriz - Iran