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Association analysis of IL-12, IL-13 and TNF-α polymorphisms with susceptibility to brucellosis

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Year: 2019
COI code: MEDISM20_355
Paper Language: English

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Authors Association analysis of IL-12, IL-13 and TNF-α polymorphisms with susceptibility to brucellosis

  Sima Kazemi - Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  Asad Vaisi–Raygani - Department of Clinical Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  Fariba Keramat - Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  Massoud Saidijam - Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  Ali Reza Soltanian - Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
  Mahdi Alahgholi-Hajibehzad - Department of Immunology, Hamadan University of Medical Sciences, Hamadan, Iran

Abstract:

Introduction & Objectives: The cytokine gene polymorphism is important for the genetic predisposition of infectious disease. The present study was aimed at identification the associations between IL-12 (+1188 A/C), IL-13 (-1512 A/C), IL-13 (-1112C/T) and TNF-α )-238 G/A) genotyping in Brucellosis patients. Materials & Methods: This case-control study was conducted on 107 Brucellosis patients and 107 healthy controls. The SNPs of TNF-α )-238 G/A) and IL-12 (+1188 A/C) were done by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and IL-13 genotyping at positions -1512 (A/C) and -1112 (C/T) were analysis by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) methods. Result: IL-13 (-1512A/C) was associated with Brucellosis risk in dominant model (OR (95% CI) =2.17 (1.02–4.62)), P-value=0.041. However, there was no difference in allele and genotype frequencies of TNF-α )-238 G/A), IL-12 (+1188 A/C) and IL-13 (-1112 C/T) between patients and controls. Conclusion: In conclusion the gene variation may be useful for identification of genotype as biomarkers for identification of people at high risk.

Keywords:

Cytokines; Polymorphisms; Brucellosis; Iran

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COI code: MEDISM20_355

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Kazemi, Sima; Asad Vaisi–Raygani; Fariba Keramat; Massoud Saidijam; Ali Reza Soltanian & Mahdi Alahgholi-Hajibehzad, 2019, Association analysis of IL-12, IL-13 and TNF-α polymorphisms with susceptibility to brucellosis, 20th International Congress of Microbiology of Iran, كرمان, دانشگاه علوم پزشكي كرمان, https://www.civilica.com/Paper-MEDISM20-MEDISM20_355.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Kazemi, Sima; Asad Vaisi–Raygani; Fariba Keramat; Massoud Saidijam; Ali Reza Soltanian & Mahdi Alahgholi-Hajibehzad, 2019)
Second and more: (Kazemi; Vaisi–Raygani; Keramat; Saidijam; Soltanian & Alahgholi-Hajibehzad, 2019)
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Type: Medical University
Paper No.: 2223
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