Delivery of Methotrexate from Nano gel- Calcium Alginate beads

The objective of this study was to develop a sustained release dosage form Methotrexate (MTX) using a natural polymeric carrier prepared in a completely aqueous environment. MTX was entrapped in calcium alginate beads prepared with sodium alginate by the ionotropic nanogel method using calcium chloride as a crosslinking agent. The drug was incorporated either into preformed calcium alginate gel beads . Fourier transform infrared (FTIR), Thermal analysis (TG/DTA), scanning electron microscope (SEM) studies on this sysytem are discussed. The controlled release of MTX from Calcium alginate beads in buffer solution has been performed and monitored by UV–visible spectroscopy

Keywords:

alginate. Calcium alginate beads. Methotrexate , SEM , drug release , Uv spectrometer