Embryonic Stem Cell-Expressed RAS, A Novel Member Of The RAS Family, Modulates Maintenance Of Liver Stem Cells AndSurvival Of Cancer Cells
Publish place: 2nd International Nastaran Cancer Symposium
Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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NASTARANCANSER02_016
تاریخ نمایه سازی: 22 دی 1396
Abstract:
RAS proteins are central components of intracellular signaling pathways. Somatic mutations havebeen identified in 1/3 of human tumors, for example 90%, 50%, 30% and 25% of pancreatic, colorectal,lung and melanoma carcinoma, respectively. Oncogenic activation of three closely related membersof RAS family (HRAS, KRAS and NRAS) is mainly due to somatic point mutations in codon 12, 13 and61. These mutations render RAS protein in its active form that contributes to cell proliferation andanti-apoptosis. However, they are also important for embryo development. Germline mutations ofRAS family members and their signaling components causes a cluster of genetic disorderscollectively called RASophathy. A novel member of this family, embryonic stem cell-expressed RAS(ERAS), has deviation at codon 12 (HRAS numbering) resulting in a constitutive active protein. ERASis not regulated at the protein level by GTPase activating proteins (GAPs) but rather at thetranscriptional levels through the DNA methylation. Unlike classical RAS isoforms (HRAS, NRASand KRAS), ERAS harbors an extended N-terminus that is important for protein-protein interactionand probably subcellular localization. In addition, we detected ERAS is differentially expressed indifferent human cancer cell lines as well as normal cells of the body, including the hepatic stellatecells. ERAS has a distinct amino acid sequence within its effector binding site that modules itscellular functions, especially by activating the PI3K-AKT-mTOR and HIPPO-MST1/2-YAP axes.
Authors
Saeideh Nakhaei-Rad
Institute Of Biochemistry And Molecular Biology II, Medical Faculty Of The Heinrich-Heine University, Düsseldorf, Germany
Inga Rebecca Heinen
Institute Of Biochemistry And Molecular Biology II, Medical Faculty Of The Heinrich-Heine University, Düsseldorf, Germany
Hossein Nakhaeizadeh
Institute Of Biochemistry And Molecular Biology II, Medical Faculty Of The Heinrich-Heine University, Düsseldorf, Germany
Mohammad R Ahmadian
Institute Of Biochemistry And Molecular Biology II, Medical Faculty Of The Heinrich-Heine University, Düsseldorf, Germany