A Brief Review Of Hyperthermia As An Neoadjuvant Therapy Method Related To Cancer Treatment

Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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NASTARANCANSER02_071

تاریخ نمایه سازی: 22 دی 1396

Abstract:

Hyperthermia refers to elevation tumor temperature from 39 up to 43 degree Celsius. TherapeuticHyperthermia has been used as an treatment modality for cancer since end of the 19th century afterobservations William Coley who found that tumor is remission after induction of fever by bacterialtoxins.Typically there are three categories for Hyperthermia, including local , regional and wholebody. Local Hyperthermia is used to solid ,localized and superficial tumors while regional isgenerally used for deeper diseases, and whole body Hyperthermia typically used for metastaticcancers. Actually the exact mechanism of direct HT-induced cell death is not well understood.Certainly clinical effects of Hyperthermia is more Based on it s combination with other modalities,and it is more important, it can sensitize tumor cells to other forms of therapy, includingRT(Radiation Thrapy) and chemotherapy(CT). Molecular effectors of hyperthermia include ; Cellmembrane Alterations in fluidity/ stability,Changes in structure;stability of plasma membrane,membrane potential, cellsurface receptors, transmembranetransport mechanisms, apoptosis,Impairment of ion transport (Ca2+, Na+, Mg+, K+); Impairment of protein synthesis, Induction ofHSP synthesis, Generation of reactive oxygen species (ROS),Impairment of RNA/DNAsynthesis,inhibition of DNA-repair mechanisms, Modification of gene expression,signaltransduction Inhibition of DNA repair enzymes,and Protein synthesis (impaired), misfolding/denaturation/nuclear aggregation.Although the role of HSPs is still under investigation, currentevidence has proved that enhanced immunogenicity and HSP expression seen after tumor cells areheated,thermally enhanced immune effector cell activation and function, thermally enhancedvascular perfusion and delivery or trafficking of immune effector cells to tumors.A randomizedclinical trial carried out by Jones et al-2005,Has reported CR rates of 23.5% for radiotherapy aloneversus 68.2% for Hyperthermia plus Radiotherapy. Conclusion:hyperthermia can be used incombination with other modalities such as radation therapy or chemotherapy that can haveadditive effect on the modalities.Actually a large number of studies document clinical effectivenessof hyperthermia in combination with RT or CT in vivo and/or in vitro condition. In spite of manystudies which has been published about HT ,at now the exact mechanism of it is unclear. Here wewill review type of method and description of cellular basic of hyperthermia related to cancertreatment,and summarise the clinical data have been documented effects of hyperthermia incombination with other modalities.

Authors

Fahimeh Faghihi Moghadam

Department Of Medical Physics, Faculty Of Medical Sciences ,Shahid Beheshti University Of Medical Science,Tehran ,Iran

Hüseyin Sahinbas

Institute For Hyperthermia Research, Partner Of The Marien Hospital Herne, Hospital Of The Ruhr-University , Bochum-Germany