Association Between Plasma Levels Of Ceruloplasmin And Adiponectin With Medullary Thyroid Carcinoma

Ceruloplasmin and Adiponectin are Adipokines with important biological role. PlasmaCeruloplasmin level increases in some cancers because of its positive effect on angiogenesis.Adiponectin is exclusively secreted from adipose tissue. Large epidemiological studies show thatobesity, which is known as one of the most important public hygiene issues, may play a role as a riskfactor for thyroid carcinoma. This study aimed in assessing serum levels of Ceruloplasmin andAdiponectin in patients with medullary thyroid Carcinoma; in the hope of finding biomarkers whichdecrease expenses and time requiring of MTC diagnosis. In this matched case-control study, 45 MTCpatients and 45 healthy controls were included. Plasma levels of Ceruloplasmin and Adiponectinwere measured by Sandwich ELISA method. .ata analyses were performed by SPSS software version22. There was no significant difference between the mean Ceruloplasmin levels of case and controlgroups (P> 0.05). MTC patients had lower Plasma level of Adiponectin in comparison with controlgroup, it was not statistically significant though. Since Ceruloplasmin and Adiponectin levels inmedullary thyroid cancer patients were the same, therefore these two Adipokines cannot be used asthe marker of these groups in order to separate them.