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Breast Cancer Cells Imaging By Targeting Gd3+-Based Silica Nanoprobe

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Year: 2016
COI code: NASTARANCANSER02_192
Paper Language: English

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Authors Breast Cancer Cells Imaging By Targeting Gd3+-Based Silica Nanoprobe

  Bita Mehravi - Radiation Biology Research Center, Iran University Of Medical Sciences, Tehran, Iran
  Khadijeh Ashtari - Department Of Medical Nanotechnology, Faculty Of Advanced Technology In Medicine, Iran University Of Medical Sciences, Tehran, IR Iran
  Hojatola Nazari - Department Of Medical Nanotechnology, Faculty Of Advanced Technology In Medicine, Iran University Of Medical Sciences, Tehran, IR Iran
  Neda iranpour - Department Of Medical Nanotechnology, Faculty Of Advanced Technology In Medicine, Iran University Of Medical Sciences, Tehran, IR Iran

Abstract:

Cancer cells diagnostic in early stage using noninvasive techniques is high global interest.Mesoporous silica nanoparticles functionalized by targeting group were further modified by loadingwith fluorescent and contrast agent with the aim of specifically targeting cancer cells imaging withreduced side effects. Due to the high abundance of folate receptors in various cancer cells, folic acidwas used as the targeting group. The intracellular uptake of this nanoprbe was analyzedquantitatively and qualitatively by inductively coupled plasma atomic emission spectroscopy (ICPAES),T1 and T2 mapping in vitro in a 3 T MRI scanner, flow cytometry, and fluorescent microscopyin cell lines expressing different levels of folate receptors. The cellular uptake of foliconanoprbewas about 62.01% in cancer cell. 2.6 times more foliconanoprbe were internalized by cancer cellsexpressing folate receptors as compared to the normal cells expressing low levels of the receptorand. Average cellular uptake of 0.7 ± 0.007 pg Gd3+ per cancer cell without any cell toxicity. The r1relaxivity of this nanoprobe in the cancer cells was measured to be 12.9 ± 1.6 mM−1s−1 and on a perGd3+ basis. These results showed that GSN provided a critical guideline in selecting thesenanoparticles as an appropriate contrast agent for nanomedicine applications.

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COI code: NASTARANCANSER02_192

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Mehravi, Bita; Khadijeh Ashtari; Hojatola Nazari & Neda iranpour, 2016, Breast Cancer Cells Imaging By Targeting Gd3+-Based Silica Nanoprobe, 2nd International Nastaran Cancer Symposium, مشهد, مركز پيشگيري سرطان نسترن - دانشگاه پزشكي مشهد و دانشگاه فردوسي, https://www.civilica.com/Paper-NASTARANCANSER02-NASTARANCANSER02_192.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Mehravi, Bita; Khadijeh Ashtari; Hojatola Nazari & Neda iranpour, 2016)
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Type: Medical University
Paper No.: 3025
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