Evaluation Cytotoxic Activities Of Schiff BaseCDerived Copper (II) Complex

Breast cancer is the most common cancer among women. Usually breast cancer either begins in thecells of the lobules, which are the milkCproducing glands, or the ducts, the passages that drain milkfrom the lobules to the nipple. Schiff base, named by the chemist Hugo Schiff, is a functional groupthat contains a double bond between carbon and nitrogen. Schiff bases play an important role ininorganic chemistry as they easily form stable complexes with most transition metal ions. Manystudies have been reported regarding the biological activities of Schiff bases, including theiranticancer, antibacterial, antifungal and herbicidal activities. Copper, is a cofactor essential for thetumor angiogenesis processes, whereas other transition metals are not. In this study, wereinvestigated the antiCproliferation properties of copper Schiff base complex N CN1 dipirodoxilC1C2diaminobenzene on breast cancer cells (Tubo). Tubo cells were cultivated and treated with differentconcentration of copper Schiff base complex (62.5, 125, 250, 500, 1000 μg/ml). The result of MTTassay showed that the cell proliferation was decreased as time and dose dependent manner withIC50 about 125μg/ml. Morphological analysis reveals changes in treated cells such as reductionvolume of cells, cell deformation and shrinkage and decrease size of cells. The results of this studyuse of Schiff base in cancer treatment offers some possibilities, including the possibility ofdestroying cancer tumors with minimal damage to healthy tissue and organs, as well as thedetection and elimination of cancer cells before they form tumors.