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Bioinformatics analysis of has-mir-769 targetome pathway and its snp function in patients with burkitt lymphoma

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Year: 2017
COI code: NASTARANCANSER03_092
Paper Language: English

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Authors Bioinformatics analysis of has-mir-769 targetome pathway and its snp function in patients with burkitt lymphoma

  Sayyid Mohammad Ghoreishi - Departement Of Biochemistry, Faculty Of Nuclear Eng & Basic Science, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran
Mansoureh Azadeh - Zist Fanavary Novin, Biotechnology Institute, Isfahan, Iran
  Negin Hoghoughi - Department Of Biology, Faculty Of Science, University Of Isfahan, Isfahan, Iran
  Kamran Ghaedi - Department Of Biology, Faculty Of Science, University Of Isfahan, Isfahan, Iran

Abstract:

cancer is a class of disease characterized by abnormal cells that grow and invade surrounding healthy cells in the body. There are over 100 different types of cancer, and each is classified by the type of cell that is initially affected.Micro RNA (miRNAs) participate in diverse biological pathways and may act as oncogenes or tumor suppressors. So they could be used as prognostic biomarkers. The aim of our study is to expand current knowledge about molecular function of has-mir-769 and its SNP in Burkitt lymphoma cells by using bioinformatics tools. validated and predicted targets of has-mir-769 wereobtained from miRtarbase and miRwalk database respectively. UniGene and DIVID database were used for further analysis. MIRNASNP database predicts single nucleotide polymorphism in has-mir-769and its function.It is predicted that hsa-miR-769 acts as a critical tumor suppressor microRNA by inhibiting some important genes in sustained angiogenesis pathway. Our data manifested KEGGsignaling pathways pathway in cancer as the most statistical relevant pathways with hsa-miR-769 targetome. According to our data, hsa-miR-769 and its SNP may be involved in Burkitt lymphomaprognosis by altering regulation of angiogenesis and some vital signaling pathways mRNAs. To sum up, C allele in this location can have prognostic value for angiogenesis and metastasis phenotypes inpatients with gastric cancer

Keywords:

Blood Cancer, Gene and Cancer, Cell and Cancer, Cancer Stem Cells, Cancer Genetics

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COI code: NASTARANCANSER03_092

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Ghoreishi, Sayyid Mohammad; Mansoureh Azadeh; Negin Hoghoughi & Kamran Ghaedi, 2017, Bioinformatics analysis of has-mir-769 targetome pathway and its snp function in patients with burkitt lymphoma, 3rd International Nastaran Cancer Symposium, مشهد, مركز پيشگيري سرطان نسترن - دانشگاه پزشكي مشهد و دانشگاه فردوسي وجهاد دانشگاهي خراسان, https://www.civilica.com/Paper-NASTARANCANSER03-NASTARANCANSER03_092.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Ghoreishi, Sayyid Mohammad; Mansoureh Azadeh; Negin Hoghoughi & Kamran Ghaedi, 2017)
Second and more: (Ghoreishi; Azadeh; Hoghoughi & Ghaedi, 2017)
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Type: Azad University
Paper No.: 8294
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