Cytotoxic activity of some methanolic extract of medicinal plants from chaharmahal and bakhtiari province

Cancer is one of the most recognized causes of global mortality. Today, many studies have investigated low-complication therapy in the various cancer treatments, including the use of natural resources as a treatment combination. In the present study, the cytotoxic effects of methanolic extract of the 13 species from Chaharmahal and Bakhtiari province were examined on MCF-7، MCF-7mx، LNCAP،C26، PC3 وB16-F10 cancer cell lines using Alamarblue reagent. According to the results, Methanolic extract of all plants except D. orieltalis on LNCAP cell line (p<0.05), Methanolic extract of A. kellalensis , S. multicaulis , P. strigasa on MCF-7mx cell line (p<0.05), Methanolic extract of A. kellalensss ، A. oliveri , A. chamaecistas on PC3 cell line (p<0.05), Methanolic extract of all plants except T. dumosum, S. obtusicrerena, D. sawyeri , S. multicaulis , N. glomerulosa on C26 cell line (p<0.05) have showed significant cytotoxic activity by reducing cell viability and increasing amount of apoptotic cell, while the results for other species have demonstrated non-cytotoxic effects. Overall, it is suggested that, plant species with cytotoxic effect can be consider as a potential anticancer component for reducing the progression of cancer in future scientific research

Keywords:

Cancer Prevention , Cell and Cancer , Nutrition and Cancer , Cancer Treatment and Management , Drugs and Cancer