The effect of car t cell therapy in treating breast cancer

Publish Year: 1396
نوع سند: مقاله کنفرانسی
زبان: English
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NASTARANCANSER03_226

تاریخ نمایه سازی: 7 اسفند 1396

Abstract:

Breast cancer is one of the leading causes of cancers among women in all around the world. Thus, considerable attention has been recently paid on finding new ways of treating patients suffering fromthis kind of cancer. Immunotherapy, also called biological therapy designed in the way to enhancement the body s natural defenses to battle against the cancer. It must be noted that it uses substances either made by the body or in a laboratory so as to improve or repair immune system function. This review focused on one of the effectual ways of immunotherapy called T cell therapy or also chimeric antigen receptor (CAR) T-cell therapy which contains: extracellular binding domain, a transmembrane domain and an intracellular signaling/activation domain and we discussed recent progress in the breast cancerimmunotherapy. These receptors allow CAR T cells to recognize the cancer cells or target tumor cells antigen in a HLA-independent manner. Inducing CMs into the CARs construction leaded todeveloping activation, proliferation and boosting survival of T cells, therefore, the CAR T cells would show quite more tumor cell-killing efficacy.

Authors

Amene Salami

Division Of Genetics, Department Of Biology, Nourdanesh Institute Of Higher Education, Meymeh,Iran

Sayedeh Zahra Shirdeli

Division Of Biotechnology, Department Of Biology, Nourdanesh Institute Of Higher Education, Meymeh, Iran