Published in: 3rd International Nastaran Cancer Symposium
COI code: NASTARANCANSER03_303
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors The association between rs2641726 single nucleotide polymorphism of muc4 gene related to hsa- mir-581 with gastric cancer incidenceMahdis Rahim Naiini - Zist Fanavari Novin, Biotechnology Institute, Isfahan, Iran
Fariba Nabatchian - Department Of Medical Laboratory Sciences, Faculty Of Allied Medicine, Tehran University Of Medical Sciences, Tehran, Iran
Afshin Moradi - Department Of Medical Laboratory Sciences, Faculty Of Allied Medicine, Tehran University Of Medical Sciences, Tehran, Iran
Mansoureh Azadeh - Zist Fanavari Novin, Biotechnology Institute, Isfahan, Iran
Abstract:Introduction: Gastric cancer is considered as the fourth most common cancer worldwide. MUC 4 is aberrantly expressed in gastric cancer. MUC4 can regulate cell apoptosis via both ErbB2 dependentand independent mechanisms. In this research, we aimed to evaluate the possible association between rs2641726 (C> A) polymorphism of MUC 4 and gastric cancer risk in the Iranian population. Materials& methods: In this case-control study, we enrolled 168 patients vs 66 healthy subjects. Allele-specific primer polymerase chain reaction (ASP-PCR) method was applied to genotype rs2641726 in patients with gastric cancer. Standard cycling was performed under the following conditions: Initial denaturation at 95 ºC for 5 min followed by 35 cycles of 94 ºC for 30 s, 55.6 ºC for 30 s, and 72 ºC for 50 s, and finally 72 ºC for 10 min. Results: According to the hardy Weinberg equilibrium, rs2641726 single nucleotide polymorphism are not associated with the gastric cancer incidence in Iranian population (P> 0.05) but we observed significant association between rs2641726 (C> A) polymorphism and control group (OR = 0.30 for A/C and C/C, P-value =<0.0001 and AIC = 265.9), Metastasis negative (OR = 0.27, P-value= 0.014 and AIC = 195.8), no Smoking (OR = 2.27, P-value =0.0004 and AIC = 92.7), H. pylori positive (OR = 2.05 for C/C, P-value =0.2 and AIC = 175.1) and Stage (Sig (Model Fitting Information) = 0.834). Conclusion: rs2641726 single nucleotide polymorphism of MUC4 gene related to hsa- miR-581 was not associated with gastric cancer incidence but some of histopathological features such as Metastasis negative, H. pylori positive, Stage and no Smoking have significant association with rs2641726 polymorphism
Keywords:Gastric Cancer, Gene and Cancer, Cell and Cancer, Cancer Risks, Cancer Genetics
COI code: NASTARANCANSER03_303
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Rahim Naiini, Mahdis; Fariba Nabatchian; Afshin Moradi & Mansoureh Azadeh, 2017, The association between rs2641726 single nucleotide polymorphism of muc4 gene related to hsa- mir-581 with gastric cancer incidence, 3rd International Nastaran Cancer Symposium, مشهد, مركز پيشگيري سرطان نسترن - دانشگاه پزشكي مشهد و دانشگاه فردوسي وجهاد دانشگاهي خراسان, https://www.civilica.com/Paper-NASTARANCANSER03-NASTARANCANSER03_303.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Rahim Naiini, Mahdis; Fariba Nabatchian; Afshin Moradi & Mansoureh Azadeh, 2017)
Second and more: (Rahim Naiini; Nabatchian; Moradi & Azadeh, 2017)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
Research Info Management
Export Citation info of this paper to research management softwares
New Related Papers
- Performance of a Transfer Learning Module with Pretrained Neural Network and Logistic Regression in Detection of Breast Carcinoma from Microphotographs of Fine Needle Aspiration Cytology Smears
- Development of Glass-Beads Filters for the Isolation, Culture, and Re-Collection of Cancer Cells from Blood
- Flavonoids Effects on Breast Cancer Tumors
- Safety and Quality of Life in the Treatment of Non-Metastasic Colorectal Cancer patients: 5-Fluorouracil versus Capecitabine
- Usefulness of Our Newly Designed Supplements for Reducing the High Risk of Pancreatic Cancer
The Above articles are recently indexed in the related subjects
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.