Original article: investigation of histopathological effects of topical application of curcumin nanoformulation on healing process of full-thickness skin ulcers

Background and Aim : Background: In everyday pathology, wounds remain a challenging clinical problem.In this study, the effect of topical use of curcumin on the healing of open skin wounds in male rats was investigated. Methods : Methods & Material: This experimental study was performed on 75 male Wistar rats weighing 300-250 rats randomly divided into control and case groups. Under general anesthesia, a square wound with a 2 * 2 cm wide skin thickness at each neck of the rat was performed under sterile conditions. Rats were randomly divided into control, experimental and positive control groups and negative control groups. Each group was divided into three smaller groups with periods of 4 , 7 and 14 days. Surgery day was considered on day zero and from day zero the wound surface was covered in the experimental group with curcumin, liposome, nano-liposomal curcumin and in the positive control group with the fenitoin cream.the amount of collagen and capilareis and gen reveiws (TGF B) measures also the number of fibroblast and Area of the wound measured. Results : Results: The results of our study showed a significant difference between the control group and the experimental group with the scrotal sclerosis and microscopic examination of the wound bed and the time needed for complete wound healing. (P <0/001). The results of this study suggest that curcumin nanoliposomes have an effect on the rate of wound healing. . Also, the effect of this substance on reducing the intensity of inflammation and increasing the wound healing in comparison with the control group is statistically significant. (p <0/001) Conclusion : Conclusion: The application of nano-liposomal curcumin on the skin s open wound appears to accelerate the healing process of the wound.

Keywords:

repair , wound , curcumin nanoliposomes , skin