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Effect of central interaction between dopamin and histamine during yawning in rats

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Year: 2012
COI code: NCNCMB01_155
Paper Language: English

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Authors Effect of central interaction between dopamin and histamine during yawning in rats

  Saeid Mahmoudi Tiemourabad - Animal science Islamic azad university of maragheh Iran
  Reza shahriyar - Animal science Islamic azad university of maragheh Iran
  variya feizbakhsh - Animal science Islamic azad university of maragheh Iran

Abstract:

In this study, the effects of intraperitoneal (ip) injection of dopamin , subcutaneous (sc) injection of atropine, and intracerebroventricular (icv) injections of histamine, chlorpheniramine (H(1)- receptor antagonist), and ranitidine (H(2)-receptor antagonist) in separate and combined treatments were investigated during yawning in rats. dopamin at a dose of 0.25 mg/kg produced the highest number of yawns. Atropine, used alone, was without effect, but physostigmine (0.25 mg/ kg, ip)-induced yawning was blocked by pretreatment with atropine (1 mg/kg, sc). Histamine at the doses of 10, 20 and 40 microg produced yawning. Chlorpheniramine and ranitidine, used alone, had no effect, whereas pretreatments with chlorpheniramine and ranitidine at the same dose of 80 microg prevented histamine (40 microg, icv)-induced yawning. The suppressive effect of chlorpheniramine was more than that of ranitidine. Histamine (10 and 40 microg, icv) enhanced, whereas chlorpheniramine and ranitidine at the same dose of 80 microg suppressed, dopamin (0.25 mg/kg, ip)-induced yawning. Atropine (1 mg/kg, sc) not only suppressed histamine-induced yawning, but also enhanced the inhibitory effect of chlorpheniramine, but not of ranitidine on yawning induced by histamine. These results indicate that muscarinic receptors mediate yawning induced by dopamin. Histamine central H(1), and to a lesser extent H(2) receptors, may be involved in histamine-induced yawning. Cholinergic muscarinic receptors, as well as histaminergic H(1) and to a lesser extent H(2) receptors, may lso be involved in the interaction between brain acetylcholine and dopamin

Keywords:

dopamin, atropine, histamine, chlorpheniramine, ranitidine, yawning, rats

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Mahmoudi Tiemourabad, Saeid; Reza shahriyar & variya feizbakhsh, 2012, Effect of central interaction between dopamin and histamine during yawning in rats, 1st National Conference on New Cellular Molecular Biotechnology, پرند, دانشگاه آزاد اسلامي واحد پرند, https://www.civilica.com/Paper-NCNCMB01-NCNCMB01_155.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Mahmoudi Tiemourabad, Saeid; Reza shahriyar & variya feizbakhsh, 2012)
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Type: Azad University
Paper No.: 1999
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