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Autoimmune Hepatitis in a person with HTLV-1 seropositivity: A rare coincident

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Year: 2017
COI code: NGCMED10_182
Paper Language: English

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Authors Autoimmune Hepatitis in a person with HTLV-1 seropositivity: A rare coincident

Seyed Mehran Homan - Department of neurology, Islamic Azad University,Razavi Khorasan Branch, Mashhad, Iran
Saba Ahmadvand - School of Medicine, Islamic Azad University, Razavi Khorasan Branch, Mashhad, Iran
  Mohammad Reza Hedayati-Moghaddam - Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch,Mashhad, Iran

Abstract:

A 56-year old male patient diagnosed with Human T Lymphocyte Virus Type 1 (HTLV-1) since 2007. He cameto our clinic to do his routine follow up procedure. Clinical examination resulted in no other findings except forrashes on his extensors beacause of his psoriatic disease. We found highly elevated serum aminotransferasesincluding AST and ALT, as well as high level of hematocrit and hemoglobin in laboratory tests. Ultrasoundimaging showed fatty liver disease (grade 1). Serologic studies were negative for Hepatitis B and C viruses.Serum levels of Iron, ferritin and ceruloplasmin were in normal range. Analysis of autoimmune markers such asantinuclear, smooth muscle, antimitochondrial,and liver-kidney microsomal type 1 antibodies were all negative.However, someevidences of autoimmune hepatitis were reportedby both two pathologists who examined thepatient’s liver specimen. Advanced liver fibrosis was shown by both transient elastography (Fibroscan) andpathology assessment. Immediate therapy with high dose prednison was initiated. This study pushes forth theidea of a possible relationship between HTLV-1 infection and various types of autoimmune disorders includingautoimmune hepatitis. Hence, finding the characteristics of this probable relationship might be a proper subjectof further studies.

Keywords:

HTLV-1, Autoimmunity, Autoimmune Hepatitis, Iran

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COI code: NGCMED10_182

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Homan, Seyed Mehran; Saba Ahmadvand & Mohammad Reza Hedayati-Moghaddam, 2017, Autoimmune Hepatitis in a person with HTLV-1 seropositivity: A rare coincident, 2nd International & 10th National Neurogenetic Congress, مشهد, دانشگاه علوم پزشكي مشهد, https://www.civilica.com/Paper-NGCMED10-NGCMED10_182.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Homan, Seyed Mehran; Saba Ahmadvand & Mohammad Reza Hedayati-Moghaddam, 2017)
Second and more: (Homan; Ahmadvand & Hedayati-Moghaddam, 2017)
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