Exosome as a natural nanocarier in immune disease
Publish place: First National Congress on Nanotechnology in Health Sciences
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
NHSMED01_065
تاریخ نمایه سازی: 18 آذر 1398
Abstract:
Abstract: Exosomes as naturally occurred nanoparticles (30-100 nm vesicles) have endosomal origin which are produce and secrete into the extracellular matrix by diverse type of cells. They have essential role in establishing intercellular communications by transferring the wide variety of proteins and different types of nucleic acids (DNA, mRNA, miRNAs, lncRNAs) from one cell to another. Depending on the cell type of exosome origin and the exosome contents(cargo), they can have immunosuppressive or immunostimulatory effects on the cell microenvironment. Therefore, they can be targeted, modified and used as a natural and efficient nanocarrier for treatment of different autoimmune diseases, including Sjogren’s syndrome (SS), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). Also, Exosomes can be isolated from different body fluids and used as novel biomarker for detection of different immune disease, because the exosomes contents is a reflection of their origin cell.
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Authors
Reza Gheitasi
MSc student of immunology, Students Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
Hamed Manoochehry
Ph.D student of medical biotechnology, Students Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
Masoumeh Beig
MSc student of Microbiology, Students Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
Mona Pourjafar
Ph.D student of medical biotechnology, Students Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.