Comparison the Effect of Pentylentetrazole and Kainic Acid Convulsive Potential

The brain is affected by severe seizure activities which can damage the brain and change its structure and function. Seizure models affect the brain differently which may have a negative impact on the outcome of the experiments. The greater the severity of the seizure, the greater the damage to the neuronal network. Therefore, in this study, the convulsive effects of kainic acid and pentyltentetrazole will be compared.Materials and Methods: In this experimental study, 24 adult male Wistar rats were allocated into two groups. In the first group, seizure was induced by a single intravenous injection petylentetrazole (30 mg/Kg i.v). The second group, a single injection of the kainic acid inside thehippocampus (4 μg/5 μl) provoked the seizure. The behavioral profile was characterized by stages defined as scores: (0) short swim, (1) increased swimming activity and high frequency of opercular movement, (2) erratic movements, (3) circular movements, (4) clonic seizurelikebehavior, (5) fall to the bottom of the tank and tonic seizure-like behavior, (6) death. Results: The results of this study showed, the latency1,2 for the onset of seizure induced by pentyltentetrazole decreased significantly compared with the kainic acid group (P<0.01). Durationof seizure (P<0.01), the percentage of tonic - clonic seizures and mortality rate in the pentyltentetrazole group increased significantly. Conclusion: Based on the results of this study, the pentylentetrazole seizure activity are stronger and faster than the kainic acid andmay have a stronger impact on the neural functions.