COI code: NIMED03_186
Paper Language: English
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Authors What Is the Combined Effect of Intense Intermittent Exercise and Ginkgo Biloba Plant on the Brain Neurotrophic Factors Levels, and Learning and Memory in Young RatsMasoumeh Sadeghinejad - Department of Sport Sciences, University of Birjand, Birjand, Iran
Zahra Soltani - Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
Abstract:The present study was conducted to investigate the effect of intense intermittent exercise and Ginkgo biloba on the hippocampal levels of brainderived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) and also memory and learning in young rats. Materials and Methods: Forty- two eight-week-old rats were randomly divided into six groups including control, low dose of Ginkgo biloba (65 mg/kg), highdose of Ginkgo biloba (100 mg/kg), exercise, exercise + low dose of Ginkgo biloba, exercise + high dose of Ginkgo biloba. The exercise protocol or Ginkgo biloba administration was six days a week for six weeks. The hippocampal levels of BDNF and NT-4 were measuredby ELISA method, and learning and memory were evaluated by Morris water maze test in all groups. Data were analyzed using SPSS software. Results: Increase in hippocampal levels of BDNF and NT-4 appeared following exercise (p <0.01). The levels do not change following exercise + Ginkgo biloba administration. However, the NT-4 level decreased in the high dose of Ginkgo biloba group (p < 0.01). Disorder in learningand memory was indicated following the use of low dose of Ginkgo biloba or exercise + low dose Ginkgo biloba administration (p < 0.001). Learning elevated in the exercise group (p < 0.05). Conclusion: Exercise in young rats may increase brain neurotrophin levels andlead to improved learning. The preventative or protective role of Ginkgo biloba against some diseases has been suggested, but its consumption in young athletes is recommended with caution.
COI code: NIMED03_186
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Sadeghinejad, Masoumeh & Zahra Soltani, 2019, What Is the Combined Effect of Intense Intermittent Exercise and Ginkgo Biloba Plant on the Brain Neurotrophic Factors Levels, and Learning and Memory in Young Rats, Third International Nervous System Inflammatory Conference and Third Student Neuroscience Festival, مشهد, دانشگاه علوم پزشكي مشهد, https://www.civilica.com/Paper-NIMED03-NIMED03_186.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Sadeghinejad, Masoumeh & Zahra Soltani, 2019)
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The University/Research Center Information:
Type: state university
Paper No.: 6766
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