Bioinformatics Evaluation and Study of MirnasRegulatory Effect on Degenerative and Cancerous Diseases

Neurodegenerative diseases include parkinson, Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS) and Alzheimer that expect for the rest, it occurs as Alzheimer disorder in the muscles and the limbs. In addition, ALS and MS are autoimmune disease. These disease are progressive and with its development in various organs, looking for many psychological complications including depression. Their prevalenceits increasing in the world and unfortunately, so far no definitive treatment has been obtained for them. MicroRNAs are a group of small non-coding RNAs that involve in regulation processes by translation inhibition. They binding to complementary sequences located in ؘ 3UTR of target mRNA. Materials and Methods: The databases of articles NCBI, MalaCards was obtained from the genes involved in these diseases in this study, databases such as miRBase, miRNASNP, MiRWALK2 and DAVID were used. Results: According to the data, were evaluated10 genes have single-nucleotide polymorphisms (SNP)s with high frequency, and 25 miRNAs for each disease. The results of the bioinformatics data showed that of these, 2miRNA: has-miR-548d-5p and 3p and has-miR- 3117-3p and 5p have the maximum power to regulatethe genes desired. Example of these genes are parkinson: GBA, TBP, MAPT, GLID2, LRRK2, Alzheimer: SOX9, SOX2, APP, A2M, PLAU, MS: MBP, IL7R, HLADRB1, PDCD1, CCR5, ALS: SOD1, FUS, DCTN1, TBK1, C9ORF72. Then it was determined by checking the directions that theirs is a close relationship between the genes of these disease together, as well as cancer genes, it also affects important cancer genes such asK-Ras, MDM2. In addition, they also affect the genes that activate the immune system such as GRB2, CAN, NFAT. Conclusion: According to the results, it can be predicted that these miRNAs are effective in controlling the expression of genes involved in neurological diseases,different types of cancers especially Leukemia as well as immune system diseases.