Effect of Aspirin and Conditioned Medium Derived Adipose Mesenchymal Stem Cells co-Administration on Myelin Repair in Lysolecithin-Induced Demyelination Model

Several lines of evidence showed the beneficial impacts of aspirin and mesenchymal stem cell (mscs) on myelin repair. In the preset study, coapplication of aspirin and conditioned media from Mscs on remyelination has been evaluated in lysolecithin (LPC)-induced demyenation of optic chiasm. Materials and Methods: All expremental procedure were carried out adult male wistar rats. LPC (1%, 2μl) was injectedinto the optic chiasm to induce. The local demyelination model. Animals underwent daily injection of conditioned medium (CM) and oral gavage of aspirin at dose of 25mg/kg. The conductivity visual signals was assessed using visual evoked potential recordings (VEP) beforeLPC injection and also on days7 and 14 post lesion. Results: Our results showed that application of CM and aspirin could significantly reduce the latency of VEP waves in LPC receiving animals. Conclusion: The number of oligodendrocyte precursor cells ( opcs) was also significantly increased in optic chiasm of overall, the results of this study suggest that co-administration of aspirin and CM enhance the myelin repair of optic chiasm in LPC- induced.