Metal nano paticles as an effective catalyst a for synthesis of Bis(indolyl)Methanes at room temperature

Bis(indolyl)methanes are most active cruciferous substances for promoting beneficial estrogen metabolism and inducing apoptosis in human cancer cells. In recent years, synthesis of this class of molecules under mild conditions have been reported,with promoters such as Montmorillonite clay K-10 trichloro-1,3,5-triazine, 8 AlPW, sodium dodecyl sulfate(SDS), ZrCl4, In(OTf)3/ionic liquid, CuBr2,MW/Lewis acids (FeCl3, BiCl3, InCl3, ZnCl2, CoCl2),NaHSO4 and Amberlyst, silica sulfuric acid (SSA),metal hydrogen sulfates, NaHSO4/ionic liquid, CAN,NBS, and Ph3CCl. However, most of the existing methods involve toxic metal ions and solvents, have high costs,use corrosive reagents and have cumbersome work-up procedures [1-3]. Fe2O3 nano particles is found to be an efficient catalyst for the condencation reaction of indoles witharomatic aldehydes toafford the corresponding bis (indolyl) methanes in high yields in acetonitril solvent.The remarkable features of this new procedure are high conversions, shorter reaction times,cleaner eaction profiles and simple experimental and work-up procedures [2

Keywords:

Bis(indolyl)methanes , Carbonyl compounds , Fe2O3 nano particles , aldehydes