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Involvement of endocannabinoid system, inflammation and apoptosis in diabetes induced liver injury: role of 5-HT3 receptor antagonist

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Year: 2019
COI code: NSCMED08_072
Paper Language: English

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Authors Involvement of endocannabinoid system, inflammation and apoptosis in diabetes induced liver injury: role of 5-HT3 receptor antagonist

  Mohammad Amini - Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
  Roya Naderi - Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  Ehsan Saboory - Zanjan Metabolic Diseases Research Center, Zanjan University of medical sciences, Zanjan, Iran
  Shiva Roshan Milani - Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  Fatemeh Asgharzadeh - Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
Farzaneh Amini - shahid motahari khoy

Abstract:

Background and Aim : Confident relationships between diabetes and liver damage have previously been established. This study was designed to evaluate hepatic inflammation, apoptosis and endocannabinoid system alterations in diabetes with or without tropisetron treatment.Methods : Rats were assigned to 5 equal groups; Control, Tropisetron, Diabetes, Tropisetron+Diabetes, and Glibenclamide+Diabetes (n=7 each group). Rats treated with tropisetron (3mg/kg) and glibenclamide (1mg/kg) for two weeks after type 1 diabetes induction.Results : Inflammatory cytokines Tumor necrosis factor alpha and Interleukin 6 (TNF- and IL-6), apoptotic cells and fatty acid amide hydrolase (FAAH) enzyme expression increased, while the expression of Cannabinoid Receptor 1 (CB1) reduced in the diabetic liver compared to control. Treatment with tropisetron reversed the inflammatory markers, apoptotic index and endocannabinoid system components. These effects were equipotent with glibenclamide, indicating that tropisetron can protect liver tissue against diabetic disturbances.Conclusion : These findings strongly support the idea that diabetes-induced liver abnormality is mediated by inflammatory reactions, apoptosis, and endocannabinoid system, and that these effects can be alleviated by using tropisetron as an antioxidant and anti-inflammatory agent.

Keywords:

Diabetes, liver Injury, 5HT3 receptor, endocannabinoid system, inflammation, apoptosis, metabolic diseases

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COI code: NSCMED08_072

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Amini, Mohammad; Roya Naderi; Ehsan Saboory; Shiva Roshan Milani; Fatemeh Asgharzadeh & Farzaneh Amini, 2019, Involvement of endocannabinoid system, inflammation and apoptosis in diabetes induced liver injury: role of 5-HT3 receptor antagonist, 8th basic and clinical neuroscience congress, تهران, دانشگاه علوم پزشكي و خدمات بهداشتي درماني ايران, https://www.civilica.com/Paper-NSCMED08-NSCMED08_072.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Amini, Mohammad; Roya Naderi; Ehsan Saboory; Shiva Roshan Milani; Fatemeh Asgharzadeh & Farzaneh Amini, 2019)
Second and more: (Amini; Naderi; Saboory; Roshan Milani; Asgharzadeh & Amini, 2019)
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Type: state university
Paper No.: 11417
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