COMPARISON OF MELATONIN AND CURCUMIN EFFECT AT THE LIGHT AND DARK PERIODS ON REGENERATION OF SCIATIC NERVE CRUSH INJURY IN RATS

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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NSCMED08_366

تاریخ نمایه سازی: 15 دی 1398

Abstract:

Background and Aim : Being one of the acute clinical problems, peripheral nerve injury can bring about a number of consequences in- cluding severe disability, reduced Quality of life (QOL) and immense costs. Currently, melatonin and curcumin are widely applied because of their immunomodulatory, anti-inflammatory, neuro-protective and antioxidant prop- erties. The present study aims to compare the effects of melatonin and curcumin during light and dark periods on sciatic nerve crush injury repair.Methods : Accordingly, rats received IP injections of curcumin (100 mg/kg) and melatonin (10 mg/kg) over two periods of light (9:00 a.m.) and dark (9:00 p.m.) for 4 weeks. In order to evaluate rats, func- tional (walking track analysis and electrophysiological measurements), histomorphometric and gastrocnemius muscle mass investigations were administered.Results : No statistically significant difference was identified between dark and light curcumin groups while curcumin groups displayed better results than did melatonin groups. In addition, dark melatonin group displayed better results than the light melatonin.Conclusion : On the whole, this study found that mela- tonin and curcumin can be used to quicken neural recovery and help treat nerve injury. It was also found that better neuroregeneration or nerve regeneration was induced when rats were treated by melatonin during the dark period while effects and injection time did not correlate in curcumin application.

Authors

Farshad Moharrami Kasmaie

Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Zohreh Jahromi

Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Arash Zaminy

Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran