Combined Immunotherapy and Conventional Chemotherapy in Cancer Patients

Despite promising success in immunotherapy of cancer patients, aconsiderable part of these patients does not reach to optimum responseto these agents such as PD-1 and PD-L1 inhibitors. Recent interest isto achieve the additive efficacy of immunotherapy in combinationwith conventional chemotherapy agents. The schedule and dosage ofchemotherapy agents like metronomic treatment can play as a gamechanger in this strategy. This integration of immunotherapy with standardcancer therapy can promote immunogenic cell death with a variousmechanism such as modulate the immune phenotype of residual tumor cells, minimize of the negative impact of tumor burden and up-regulationthe expression of tumor antigen.

Keywords:

Immunotherapy metronomic treatment , Chemotherapy