Association between Transforming Growth Factor Alpha TaqI Polymorphism and Susceptibility to the Nonsyndromic Cleft Lip and/or Palate in an Iranian Population: A Case Control Study
Publish place: 1st international congress of perinatology 7th national congress of perinatology & neonatology
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
PNMED07_196
تاریخ نمایه سازی: 18 تیر 1398
Abstract:
Background: The TGF-α TaqI C> T polymorphism is a well-characterized variant for nonsyndromic cleft lip and/or palate (NS CL/P), but it has shown inconsistent results of association with nonsyndromic CL/P across a number of studies. Thus, we have performed this case-control study to clarify the association between the TGF-α TaqI C> T polymorphism and NS CL/P risk.Methods: One-hundred ten cases with NSCL/P and 110 controls were recruited to the current study. We have genotyped the TGF-α TaqI C> T polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The odds ratio (OR) and 95% confidence interval (CI) were applied for strength of association TGF-α TaqI C> T polymorphism with NSCL/P.Results: The TGF-α TaqI C> T polymorphism CC, CT and TT genotypes frequencies in the NSCL/P cases were 30.9%, 57.3% and 11.8%, respectively while the corresponding frequencies in the controls were 37.3%, 52.7% and 10.0%, respectively. The frequency of C and T alleles in the case were 59.5% and 40.5%, respectively while the corresponding allelic frequencies in the controls were 63.6% and 36.4%. There was no significant difference in the genotype and allele frequency for TGF-α TaqI C> T polymorphism between cases and controls. The minor allele frequency (MAF) of TGF-α TaqI C> T polymorphism among healthy controls was 0.36.Conclusion: Our study indicates that the TGF-α TaqI C> T polymorphism was not significantly associated with increased risk of NS CL/P in the Iranian population. However, our results still need to be confirmed by further large and well-designed case-control studies
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Authors
Abdolhamid Amooee
Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Seyed Mohammadreza Niktabar
Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Majid Morovati-Sharifabad
Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran
Mohammad Javad Akbarian-Bafghi
Department of Health Care Management, Bam University of Medical Sciences, Bam, Iran