The effects of auger electrons on DNA damages for proton therapy treatment method
Publish place: Twenty-second Annual Iranian Nuclear Medicine Conference
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
RINMMICMED22_059
تاریخ نمایه سازی: 30 آذر 1398
Abstract:
Background: In this study to see the effects of Auger electrons on the DNA breaks, the number of DNA single-strand breaks (SSB) and double-strand breaks (DSB) due to direct effects of proton beams in a water phantom by considering Auger electrons and without them to predict the effect of proton therapy on the destruction of cancer cells has been calculated.Methods: A DNA model based on realistic data for the B-DNA atomic structure of nucleotide pair up to the chromatin fiber organization level is simulated by Monte Carlo simulations. The SSB and DSB calculated by using the Geant4-DNA toolkit at different depths of the phantom with considering Auger electrons.Results: The total SSB yield in the entrance point rather than the process without auger electrons is about %5 bigger and at the Bragg peak depth this percent is about %3. The effect of auger electrons on DSB damage yields that leads to destruction of cancer cells is more than this effect on the SSB yields and these percents are about %10 and %8 for the first and last point.Conclusion: In terms of the results in this study, the auger-electrons should be considered because of their short range in biological tissues and depositing their energy in volumes at the nanoscopic scale (of the order of DNA) and so they will cause enhanced DNA damages and as a result can increase the biologic effects of proton beams.
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Authors
Zahra Ahmadi Ganjeha
Department of Physics, Yazd University, Yazd, Iran
Mohammad Eslami-Kalantari
Department of Physics, Yazd University, Yazd, Iran
Mahdy Ebrahimi Loushab
Department of Physics, Faculity of Rajaee, Quchan Branch, Technical and Vocational University, Quchan, Khorasan Razavi
Ali Asghar Mowlavic
Department of Physics, Hakim Sabzevari University, Sabzevar, Iran - International Centre for Theoretical Physics (ICTP), Associate and Federation Schemes, Medical Physics Field, Trieste, Italy