Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes

Background: With an incidence of 5-8% worldwide, polycystic ovary syndrome (PCOS) is considered one of the most prevalent endocrinopathies in women of reproductive age.Objective: To explore assisted reproductive outcomes among women with different polycystic ovary syndrome (PCOS) phenotypes.Materials and Methods: A retrospective cohort study included women with PCOS who were treated at Yazd Research and Clinical Center for Infertility, Yazd, Iran, using the GnRH antagonist protocol between April 1, 2015, and August 31, 2017. Clinical pregnancy was the primary outcome, and chemical pregnancy, implantation rate, fertilization rate, and spontaneous abortion rate, were the secondary outcomes that were evaluated among four defined phenotypes of women with PCOS.Results: Significant differences were observed between the phenotypes for the levels of luteinizing hormone, anti-Müllerian hormone, fasting blood sugar, and total testosterone concentration; similarly, the percentage of women with luteinizing hormone/ follicle stimulating hormone ratio of at least 2.5 differed between PCOS phenotypes (all p<0.001). There were also significant differences in estradiol level (p<0.001) and the number of matured follicles (p=0.002) between different phenotypes. No significant differences were observed in the fertilization and implantation rates, as well as chemical and clinical pregnancy rates (all p> 0.05).Conclusion: No significant differences were observed in assisted reproductive technique outcome among women with different phenotypes of PCOS undergoing frozen-thawed embryo transfer.

Keywords:

Assisted reproductive technology , Fertilization rate , Implantation rate , Ovarian hyperstimulation , PCOS , PCOS phenotypes , Pregnancy rate , Spontaneous abortion rate