Current Options for Medical Treatments of Male In-fertility

Apart from assisted fertilization and surgery male infertility/ subfertility can be treated with a variety of drugs. As up to 50% of male fertility disturbances are classified as idiopathic no clear selection criteria for this kind of treatment are available in these cases. That is why only empiric treatment approaches can be tried. Drugs used comprise antiestrogens such as tamoxifen and clomophene, recombinant or highly purified FSH as well as aromatase inhibitors and antioxidants. Recent studies show the best results after FSH therapy. Effective treatment regimens are available for retrograde ejaculation by administration of α-sympathomimetics, imipramine or brompheniramine.When male fertility disturbances are associated with inflamma-tion/infection of the genital tract treatment with nonsteroidal antiphlogistic drugs and/or antibiotics is possible. However, there is only low evidence due to a limited number of only small studies. Follow-up therapies with mastcell blockers or gluco-corticosteroids as well as antioxidants have partly revealed promising results, whereas glucocorticosteroids are not recom-mended for immunological infertility.

Keywords:

Male Fertility Disturbances , Drug Treatment , FSH , Antiestrogens , Genital Tract Inflammation , Antiphlogistics An-tioxidants