Epidemiology and clinical features of infective endocarditis: A retrospective study of 57 patients in a tertiary university hospital in Iran

Backgroud and aim: Infective endocarditis IE is a life-threatening infectious disease. In order to define the epidemiologic characteristics of infective endocarditis in our region, we studied .infective endocarditis cases over a 7-year period in tertiary teaching and referral hospitals Material and Methods: Medical records of all hospitalized patients diagnosed with IE at teaching hospitals of Urmia University of Medical Sciences, Iran, from 2009 to 2016, were retro spectively reviewed. patients who met the modified Duke criteria for definite or possible IE .were included Results: The study included 57 patients 35 males, 22 females; mean age 40 years who were diagnosed as having definite IE, according to the modified Duke criteria. 15 cases 26.31% had Rheumatic heart diseases RHD , 12 cases 21.06% had End Stage Renal Disease ESRD , 6 cases 10.53% had Congenital Heart Disease CHD , 10 cases 17.54% had Injection Drug User IDU and 14 cases 24.57% had no significant cardiac disease. The primary clinical manifestations that were observed included 48 cases with fever 84.2% , 35 cases with anemia 61.4% and 6 cases 11.1% with altered mental status. Of the total 57 patients, blood cultures were positive in 52 64.91% of cases. the leading causative microorganism were Staphylococcus aureus, isolated in 19 cases 51.35% , followed by Gram nega tive bacilli in 6 cases 16.22% and Streptococcus spp. in 12 cases 32.43% . In-hospital death . occurred in 9 patients 16.7% Conclusion: Changes in IE profile required continuous epidemiological updates. In this study, IE were most common in men. Staphylococcus aureus and streptococcus spp. Remain the most.common etiologic agents. ESRD and IDU was important predisposing factors for IE

Keywords:

Infective endocarditis , Epidemiology , Risk factors