COI code: SRCCG05_103
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors Lack of Correlation Between the CCR5-D32 Mutation and Acute Myeloid Leukemia in Iranian PatientsHossein Khorramdelazad - Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Yousef Mortazavi - Department of Molecular Medicine, Faculty of Medicine, Zanjan University of Medical Sciences Zanjan, Iran.
Mohammad Momeni - Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences Rafsanjan, Iran.
Mohammad Kazemi Arababadi - Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences,Rafsanjan, Iran ; Immunology of Infectious Diseases Research Center, Rafsanjan University of MedicalSciences, Rafsanjan, Iran
Behjat Kalantary Khandany - Department of Hematology-Oncology and BMT, Kerman University of Medical Sciences, Kerman, Iran.
Mozhgan Moogooei - Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Abstract:Introduction: Chemokines and their receptors are crucially important in the pathogenesis of acute myeloblastic leukemia AML . The CC chemokine receptor 5 CCR5 is a specific chemokine receptor for CC chemokine ligand 3 CCL3 , CCL4 and CCL5 which all play key roles in identifying cancer properties and localization of leukemia cells. It has been demonstrated that the known mutation in CCR5 gene CCR5-D32 leads to mal-expression of the .receptor and affect its function Purpose: The aim of this study was to determine the rate of CCR5-D32 mutation within Iranian AML patients Materials and Methods: In this study, blood samples were obtained from 60 AML patients and 300 healthy controls. The CCR5-D32 mutation was evaluated using Gap-PCR techniqueResults: Our results showed that CCR5-D32 mutation was not found in the patients, whilethree out of the controls had hetrozygotic form of this mutation. The rest of studied sam- .ples had the wild form of the gene Conclusion: According to these findings, it can probably be concluded that the CCR5-D32 is .not associated with susceptibility to AML in Iranian patients
Keywords:CCR5-D32 mutation, Acute myeloblastic, leukemia, Chemokine
COI code: SRCCG05_103
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Khorramdelazad, Hossein; Yousef Mortazavi; Mohammad Momeni; Mohammad Kazemi Arababadi; Behjat Kalantary Khandany & Mozhgan Moogooei, 2019, Lack of Correlation Between the CCR5-D32 Mutation and Acute Myeloid Leukemia in Iranian Patients, 5th congress of student research committee of rafsanjan university of medical sciences, رفسنجان, دانشگاه علوم پزشكي رفسنجان, https://www.civilica.com/Paper-SRCCG05-SRCCG05_103.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Khorramdelazad, Hossein; Yousef Mortazavi; Mohammad Momeni; Mohammad Kazemi Arababadi; Behjat Kalantary Khandany & Mozhgan Moogooei, 2019)
Second and more: (Khorramdelazad; Mortazavi; Momeni; Kazemi Arababadi; Kalantary Khandany & Moogooei, 2019)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
The University/Research Center Information:
Type: Medical University
Paper No.: 288
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.
Research Info Management
Export Citation info of this paper to research management softwares
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.