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Lack of Correlation Between the CCR5-D32 Mutation and Acute Myeloid Leukemia in Iranian Patients

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Year: 2019
COI code: SRCCG05_103
Paper Language: English

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Authors Lack of Correlation Between the CCR5-D32 Mutation and Acute Myeloid Leukemia in Iranian Patients

  Hossein Khorramdelazad - Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
  Yousef Mortazavi - Department of Molecular Medicine, Faculty of Medicine, Zanjan University of Medical Sciences Zanjan, Iran.
  Mohammad Momeni - Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences Rafsanjan, Iran.
  Mohammad Kazemi Arababadi - Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences,Rafsanjan, Iran ; Immunology of Infectious Diseases Research Center, Rafsanjan University of MedicalSciences, Rafsanjan, Iran
  Behjat Kalantary Khandany - Department of Hematology-Oncology and BMT, Kerman University of Medical Sciences, Kerman, Iran.
  Mozhgan Moogooei - Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Abstract:

Introduction: Chemokines and their receptors are crucially important in the pathogenesis of acute myeloblastic leukemia AML . The CC chemokine receptor 5 CCR5 is a specific chemokine receptor for CC chemokine ligand 3 CCL3 , CCL4 and CCL5 which all play key roles in identifying cancer properties and localization of leukemia cells. It has been demonstrated that the known mutation in CCR5 gene CCR5-D32 leads to mal-expression of the .receptor and affect its function Purpose: The aim of this study was to determine the rate of CCR5-D32 mutation within Iranian AML patients Materials and Methods: In this study, blood samples were obtained from 60 AML patients and 300 healthy controls. The CCR5-D32 mutation was evaluated using Gap-PCR techniqueResults: Our results showed that CCR5-D32 mutation was not found in the patients, whilethree out of the controls had hetrozygotic form of this mutation. The rest of studied sam- .ples had the wild form of the gene Conclusion: According to these findings, it can probably be concluded that the CCR5-D32 is .not associated with susceptibility to AML in Iranian patients

Keywords:

CCR5-D32 mutation, Acute myeloblastic, leukemia, Chemokine

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COI code: SRCCG05_103

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Khorramdelazad, Hossein; Yousef Mortazavi; Mohammad Momeni; Mohammad Kazemi Arababadi; Behjat Kalantary Khandany & Mozhgan Moogooei, 2019, Lack of Correlation Between the CCR5-D32 Mutation and Acute Myeloid Leukemia in Iranian Patients, 5th congress of student research committee of rafsanjan university of medical sciences, رفسنجان, دانشگاه علوم پزشكي رفسنجان, https://www.civilica.com/Paper-SRCCG05-SRCCG05_103.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Khorramdelazad, Hossein; Yousef Mortazavi; Mohammad Momeni; Mohammad Kazemi Arababadi; Behjat Kalantary Khandany & Mozhgan Moogooei, 2019)
Second and more: (Khorramdelazad; Mortazavi; Momeni; Kazemi Arababadi; Kalantary Khandany & Moogooei, 2019)
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Type: Medical University
Paper No.: 288
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