Influence of ultrasound on the clearance of toxic substances from Polysulfone hollow fiber membrane used in a dialyzer filter

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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SRMMED22_296

تاریخ نمایه سازی: 19 آبان 1398

Abstract:

Introduction: The aim of this work was to investigate the potential of high frequency ultrasound for the cleaning of a Polysulfone (PSU) ultrafiltration membrane used in hemodialysis. Materials and Methods : The blood substitute solution flowing through the hollow fiber membrane used in the High Flux F60 dialyzers has been sonicated by ultrasonic (US) waves with 1 MHz frequency and 2 W/cm2 in situ intensity The solution was comprised of toxic compounds such as Urea, Creatinine, Vitamin B12 and Inulin. The effect of US was represented by comparison of the clearance in both OFF and ON ultrasound conditions. Results:The results of these studies have been demonstrated that US can enhance the permeability of the PSU dialyzer membrane revealed that US had significant effect (p-value ˂ 0.05) on the clearance of Inulin as a large molecule (5200 D) and accelerated its filtration by 28%. The proposed dialysis method can be used alongside the existing dialysis machine. Conclusion: The dialysis acceleration device proposed in this study could reduce the time necessary for dialysis and potentially save thousands of man hours for physicians, nurses, technicians, and patients, with enormous economic profit. It may be beneficial to the development of such an innovative ultrasound technology. This technology can be used as a complementary to existing dialysis equipment.

Authors

Mohammad Hossein Jelodar Nasery

Student Research Committe,Behbahan Faculty of medical Science,Behbahan,Iran

Behrouz Rasuli۱

Department of Radiology Technology, Behbahan Faculty of Medical Sciences, Behbahan, Iran

Mostafa Lotfi

Student Research Committe,Behbahan Faculty of medical Science,Behbahan,Iran

Freshte Kowsari

Student Research Committe,Behbahan Faculty of medical Science,Behbahan,Iran