Nanocatalyst based on heteropolyacid supported on clay as catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions

A simple and efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones or 3,4-dihydropyrimidin-2(1H)-thiones is described, using 20% w/w Cs2.5H0.5PW12O40/K-10 as a solid acidcatalyst from an aldehyde, 1,3-dicarbonyl compound, and urea or thiourea at 80 °C under solvent-freeconditions. Short reaction times, high yields, easy work-up, use of environmentally friendly catalyst and absence of organic solvents makes this method efficient and environmentally benign

Keywords:

Biginelli reaction , solid acid catalyst , 3 , 4-dihydropyrimidin-2(1H)-ones , solvent-free condition , heteropolyaci d