ONE-POT THREE-COMPONENT SYNTHESIS OF 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES BY FE3O4@SIO2/SCHIFF BASE COMPLEX OF CU()

Fe3O4@SiO2/Schiff base complex of Cu(II) efficiently catalyzes condensation reaction of isatoic anhydride, aldehydes, and primary amines or ammonium salts to afford the corresponding 2,3-dihydroquinazolin-4(1H)-one derivatives in ethanol under reflux conditions. This method gives notable advantages such as easy work-up, high yields, short reaction times. Also, the aforementioned nanocatalyst can be easily recovered by a magnetic field and reused for subsequent reactions for at least 8 times without noticeable deterioration in catalytic activity.

Keywords:

2 , 3-Dihydroquinazolin-4(1H)-ones , Isatoic anhydride , One-pot synthesis , Magnetic nanocatalyst , Recyclable catalyst