A NOVEL SYNTHESIS OF TETRAHYDROPYRIMIDIN-4-YL-2,3-DIHYDROPHTHALAZINES BY Fe3O4@SiO2-SO3H NANOPARTICLES UNDER SOLVENT-FREE CONDITIONS

Three-component coupling of phthalhydrazide, aldehydes, and barbituric acid has been accomplished in the presence of 5mgr nano-Fe3O4@SiO2-SO3H under solvent-free conditions to afford the corresponding tetrahydro-2,6-dioxopyrimidin-4-yl)-2,3-dihydrophthalazine-1,4-dione derivatives in excellent yields. This method provides high yields, shorter reaction time, and mild reaction conditions. This is the first example of the condensation of phthalhydrazide, aldehydes, and barbituric acid to provide a novel series of phthalhydrazide derivatives in the presence of nanocatalysts

Keywords:

Tetrahydro-2 , 6-dioxopyrimidin-4-yl)-2 , 3-dihydrophthalazine-1 , 4-dione derivatives , Barbituric acid , Nano-Fe3O4@SiO2-SO3H , Magnetic nanoparticle