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The Role of Brain Mitochondria in Hepatic Encephalopathy: Potential Therapeutic Targets

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Year: 2019
COI code: TOXICOLOGY15_037
Paper Language: English

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Authors The Role of Brain Mitochondria in Hepatic Encephalopathy: Potential Therapeutic Targets

R Heidari - Pharmacutical Sciences Research Center
  A Jamshidzadeh - Pharmacutical Sciences Research Center- Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
  Hadi Niknahad - Pharmacutical Sciences Research Center- Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract:

Introduction: Hepatic encephalopathy (HE) is a critical CNS complication ensued liver failure. HE is associated with increased free radical formation, tissue inflammation, disturbed neurotransmission, astrocytes swelling, brain edema, and brain herniation. Ammonia, involved in HE, is a neurotoxin which induces a wide range of CNS functional disturbances. Ammonia-induced oxidative stress, mitochondrial dysfunction, and energy crisis are known as the major mechanisms of brain injury in HE. Hyperammonemia also affects the liver and hepatocytes. In view of the severe CNS complications ensued HE, potential therapeutic points of intervention need to be investigated. A role for CNS mitochondrial damage and energy crisis has been considered in HE. It has been found that ammonia induces collapse of mitochondrial membrane potential, induced mitochondrial swelling, and increased reactive oxygen. Hence, ammonia-induced mitochondrial injury and compromised brain energy metabolism might play a vital role in the pathogenesis of ammonia neurotoxicity. Therefore, targeting mitochondria seems to be a therapeutic point of intervention in the treatment of HE. This study focuses on the concept that mitochondrial dysfunction and cellular energy crisis indeed plays a critical role in the pathogenesis of hyperammonemia-induced brain injury. Further, we will highlight the potential therapeutic value of mitochondrial protecting agents and energy providers in the management of HE. The data collected in this study might provide clues to new therapeutic interventions aimed at minimizing HE-associated complications.

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COI code: TOXICOLOGY15_037

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Heidari, R; A Jamshidzadeh & Hadi Niknahad, 2019, The Role of Brain Mitochondria in Hepatic Encephalopathy: Potential Therapeutic Targets, 15th iranian congress of toxicology, تهران, دانشگاه علوم پزشكي شهيد بهشتي, https://www.civilica.com/Paper-TOXICOLOGY15-TOXICOLOGY15_037.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Heidari, R; A Jamshidzadeh & Hadi Niknahad, 2019)
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