Evaluation of Minerals and Rare Elements in Patients with Breast Cancer: Review of Evidence

Introduction & Aim: Breast cancer is the most common type of cancer in women. At the onset of the development of breast tumors, a combination of internal and external factors is involved, including rare elements. The aim of this study was to determine the level of minerals and rare elements in patients with breast cancer. Methods: This systematic review took place by searching the databases Magiran, SID, Google scholar, Pubmed, Amedeo and elmnet with keywords Breast cancer, minerals, selenium, zinc,copper, folate and vitamin D during 2000 to 2018. In this study, descriptive, analytical and casecontrol articles have been used Results: The results of various studies showed that there was a significant difference between the mean of copper, selenium, folate and vitamin D in the group of patients with breast cancer and control subjects. Also, with these age groups, these minerals increased in these patients. There was a controversy between the mean on the patients and the control group. In these studies, generally, as a case control, a healthy group was also evaluated. The concentration of these minerals was measured using optical methods. Conclusions: Based on the results, it can be suggested that changes in trace elements in serum levels in breast cancer patients are a prognosis for diagnosis and treatment of this disease. Further studies on these elements and other important elements such as iron are also proposed

Keywords:

Breast cancer , minerals , selenium , zinc , copper , folate , vitamin D