Effect of air pollution and traffic on uterus cancer

Background:Air pollution, particularly from vehicle exhaust, has been shown to influence hormonal activity. Due to increasing concerns regarding air pollution and uterus cancer, we conducted a population-based study evaluating the association between traffic-related hazardous air pollutants and the uterus tumors Methods:we performed systematic review of literature with related keywords in PubMed,Science direct and Google scholar to gather information in articles published since 2016 and summarized here Result: Proximity to major roadways and outdoor levels of PM less than 10 microns (PM10) or 2.5 microns (PM2.5) or between 10 and 2.5 microns (PM10–2.5) in diameter were determined for 85,251 women aged 25–42 at enrollment in the Nurses’ Health Study II who were alive and responding to questionnaires, premenopausal with intact uteri, without diagnoses of cancer, or prevalent uterine leiomyomata. Incidence of ultrasound- or hysterectomy-confirmed uterine leiomyomata and covariates were reported on biennial questionnaires sent through May 2007. Multivariable time-varying Cox proportional hazard models were used to estimate the relation between distance to road or PM exposures and uterine leiomyomata risk.During 837,573 personyears of follow-up, there were 7,760 incident cases. Living close to a major road and exposuresto PM10 or PM10–2.5 were not associated with an increased risk of uterine leiomyomata. However, each 10 μg/m3 increase in 2-year average, 4-year average, or cumulative average PM2.5 was associated with an adjusted hazard ratio (HR) of 1.08 (95% confidence interval (CI):1.00–1.17), 1.09 (95%CI:0.99–1.19) and 1.11 (95%CI:1.03–1.19), respectively. Conclusion:Combustion of coal, diesel fuel and wood is the likely source of air pollution that affects cancer risk on a large scale, through production of black carbon aerosols with adsorbed polycyclic aromatic hydrocarbons and Chronic exposure to PM2.5 may be associated with a modest increased risk of uterine leiomyomata

Keywords:

air pollution , traffic , uterus cancer