Chitosan Nonocomposite Scaffolds and Wound Healing
Publish place: Third International Congress and Fifth National Congress on Wound and Tissue Restoration
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
WTRMED05_034
تاریخ نمایه سازی: 5 آذر 1397
Abstract:
Chitosan-based scaffolds are used as a natural material in regenerative medicine. Because it has anti-bacterial, anti-fungal and non-toxic properties. So, using chitosan-based biomaterials are useful in wound healing. B-chitin/HA nanocomposite scaffolds were synthesized from a mixture of B-chitin hydrogel and nHA by freeze-drying technique. The cytocompatibility of the nanocomposite scaffolds was studied using Vero, NIH 3T3 and HDF cells. The results indicated non-toxicity with enhanced attachment and proliferation of these cells onto the nanocomposite scaffolds. Similar results were observed with alpha-chitin/HA nanocomposite scaffolds synthesized from alpha-chitin hydrogel and nHA by freeze-drying approach. These results essentially signify that the synthesized nanocomposite scaffolds can serve as potential candidates for wound tissue engineering. Similar concepts could be thought of for regenerating other tissues or organs using chitosan scaffolds. Further studies are needed to demonstrate the potential uses of chitosan scaffold in the tissue engineering/regenerative medicine area.
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Authors
Gholamreza Kaka
Ph.D, Cell & Developmental Biology, Kharazmi University, Tehran, Iran
Mehrnaz Moattari
Ph.D, Cell & Developmental Biology, Kharazmi University, Tehran, Iran
Farahnaz Moattari
Ph.D, Cell & Developmental Biology, Kharazmi University, Tehran, Iran
Homa Kouchesfehani
Ph.D, Cell & Developmental Biology, Kharazmi University, Tehran, Iran