Cell Viability Induction by PVA/CMC Nanofiber to Wound Healing
Publish place: Third International Congress and Fifth National Congress on Wound and Tissue Restoration
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
WTRMED05_046
تاریخ نمایه سازی: 5 آذر 1397
Abstract:
Nowadays, tissue engineering extremely used for different healing types of the skin wound and skin tissue repair. In this study, full-thickness excisional wound healing is considered by tissue engineering methods. At first, nanofiber scaffolds prepared by electrospinning in different ratio of polyvinyl alcohol/ carboxy-methyl chitosan (2, 3, 4 and 5%) and is cross-linked by glutaraldehyde. Morphology of nano-fibers was studied by SEM and cell viability rate on the scaffolds evaluated by MTT assay using human fibroblasts (HDF) and human placental mesenchymal stem cells (PMSCs). Our results indicated that the PVA/CMC 4% scaffold could provide cell viability. It seems that this type of the scaffold can be used for wound healing also, can accelerate the healing range in full-thickness excisional wounds.
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Authors
Alireza Akbari Soreh
MSc, Student of Biology - Tissue Engineering Science and Research Branch, Islamic Azad University, Tehran, Iran
Shiva Irani
MSc, Student of Biology - Tissue Engineering Science and Research Branch, Islamic Azad University, Tehran, Iran
Shahram Rabbani
MSc, Student of Biology - Tissue Engineering Science and Research Branch, Islamic Azad University, Tehran, Iran
Mojgan Zandi
MSc, Student of Biology - Tissue Engineering Science and Research Branch, Islamic Azad University, Tehran, Iran