Role of Proteins in Wound Healing

Wound healing is a restoration of the structure and function of the tissue damaged through the reconstruction and replacement processes. Wound healing is important because skin is the first agent to protect the body from external factors. Damage to the skin can cause infection and disturbed of homeostasis .The three repair mechanisms after tissue injury are inflammation, proliferation and tissue remodeling. In the inflammatory phase, vascular permeability and cellular absorption increase .monocytes differentiate into macrophages. After a few days of wound healing proliferation phase begins.in this phase, fibroblasts and collagen are replicated. The tissue remodeling phase leads to collagen repair and contraction of the wound. A number of proteins play a role in the wound healing process; including : bFGF (Fibroblast growth factor),Occluding and claudin-1,Anti –inflammatory cytokines, Tight -Junction proteins,P53,IL6,IL4,TNF-alpha (tumor necrosis factor alpha),IL1B,Fibulin-5,TGF-B3 (transforming growth factor beta3),HSP90alpha. in this paper, proteins that play an important role in the wound healing process were investigated. Study of proteins involved in wound healing, can be developed new methods for improving the wound healing.

Keywords:

Proteins , Wound Healing , bFGF , Tigh-Junction Proteins , Wound Healing phase