Design and production of an advanced wound dressing based on natural polymers in combination with specified nanoparticles for the treatment of infected wounds

One of the main medical options for the treatment of wounds is the use of appropriate topical dressings which play an important role for correcting the underlying causes of non-healing wounds and, therefore, to aid during the healing process. Wound dressings have evolved from natural origin materials that simply covered the wound to advanced materials specially designed to provide particular effects for a specified wound. The wound dressings develop up to now have been produced with different materials and with various physical forms. So far, to improve the antimicrobial properties of dressing, several agents such as nanoparticles have been incorporated within structure of dressing. A variety of strategies, comprising distinct material and antimicrobial agents have been used to confer bactericidal activity to dressings. However, despite of developments attained so far, further improvements of these types of dressings are demanded. The purpose of this study was to design and produce a functional and advanced wound dressing based on natural polymer with efficient nanoparticles to improve the stability while having antibacterial effects. Here, an optimal formulation of zinc oxide and graphene oxide nanoparticles on chitosan polymer substrate was used for production a film. Investigation and examination of water absorption, mechanical strength, and antimicrobial properties of these films clearly confirmed the use of these films as antibacterial wound dressings. Taken together, we produced of an advanced wound dressing with an acceptable biocompability and biodegradability and no toxicity for the treatment and healing of infected wounds

Keywords:

Wound dressing , Infected wounds , natural biopolymer