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title

Cold plasma is a novel method to treat diabetic foot ulcer infection

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Year: 2019
COI code: WTRMED06_197
Paper Language: English

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Authors Cold plasma is a novel method to treat diabetic foot ulcer infection

  Mohammad Reza Amini - Diabetes Research Center, Tehran University of Medical Sciences, Tehran, Iran
Shahriar Mirpour -
Sara Fathollah -
Parvin Mansouri -
M Ghoranneviss -
B Larijani -

Abstract:

Background: Cold atmospheric plasma (CAP) is shown to decrease bacterial load in chronic wounds. It is also presented as a novel approach in healing the wounds in both in vitro and in vivo experiments.Objective: We aimed to implement the first randomized clinical trial in use of CAP in diabetic foot ulcers.Methods: Patients with diabetic wound (n=44) were randomized to receive standard care (SC, n=22) without or with CAP applied three times a week for three consecutive weeks (SC+CAP, n=22). CAP was generated from ionized helium gas in ambient air and driven by high voltage (10 kV) and high frequency (6 kHz) power supply. The primary outcomes were wound size, number of cases reached wound size of <50%, and bacterial load over three weeks of treatment.Results: Treatment with CAP was effective in reducing the fraction of wound size (p=0.02). After 3 weeks, the number of wounds that reached the fraction of wound size of ≤ 50% was significantly more in SC+CAP group (77.3%) compared with the SC group (36.4%) (p = 0.006). The mean of fraction of bacterial load counts in each session ‘after CAP exposure’ was significantly less than ‘before exposure’ measures.Conclusion: CAP could be an effective method for accelerating wound healing in diabetic foot ulcers. It also exerts immediate antiseptic effects, which seems not to last for a long time.

Keywords:

Cold Plasma; Diabetic Foot Ulcer; Infection

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COI code: WTRMED06_197

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Amini, Mohammad Reza; Shahriar Mirpour; Sara Fathollah; Parvin Mansouri; M Ghoranneviss & B Larijani, 2019, Cold plasma is a novel method to treat diabetic foot ulcer infection, 4th international and 6th national congress of wound an tissue repair, تهران, مركز تحقيقات ليزر در پزشكي جهاد دانشگاهي, https://www.civilica.com/Paper-WTRMED06-WTRMED06_197.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Amini, Mohammad Reza; Shahriar Mirpour; Sara Fathollah; Parvin Mansouri; M Ghoranneviss & B Larijani, 2019)
Second and more: (Amini; Mirpour; Fathollah; Mansouri; Ghoranneviss & Larijani, 2019)
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Type: Medical University
Paper No.: 6411
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