Vahideh Farjadi - Department of Microbiology, Faculty of Science, Islamic Azad University, Qom Branch, Qom, Iran
Hamid Abtahi - Molecular and Medicine Research Center, Department of Microbiology, Arak University of Medical Sciences, Arak, Iran
Mohammadreza Zolfaghari - Department of Microbiology, Faculty of Science, Islamic Azad University, Qom Branch, Qom, Iran
Safieh Soufian - Department of Biology, Payame Noor University, Arak, Iran

The gram negative, microaerophilic bacterium Helicobacter pylori colonizes the human gastric mucosa and causes atrophic gastritis, peptic ulcer, and gastric carcinoma. The cytotoxin-associated gen A (CagA) is one of the most important virulence factors in H.pylori. The aim of the present study was to construct a recombinant protein containing antigenic regions of cagA and determining its antigenicity as a vaccine candidate of H. pylori

Helicobacter pylori, cagA gene, antigenicity, antigenic regions