Elham Ghanbarpanah - Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
Leila Kohan - Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
Mohammad Mohammadianpanah - Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Sedigheh Tahmasebi - Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Introduction & Aim: The recurrence of breast cancer (BC) is a major cause of cancer death in females. Mir-34b/c negatively regulates many cancers, by P53 gene targeting. The aim of our study was to examine association of the miR-34b/c rs4938723, with the recurrence of BC.Methods: The present study was done on 424 females with BC (102 patients with the recurrence of BC, as the case group, and 322 women without any recurrence of BC, as the control group). After DNA extraction from peripheral blood, genotype determination was done using Tetra ARMS PCR Technique. Thereafter, the genotype and allele frequency of miR-34b/c rs4938723 was compared between the two groups. Results: The results were shown that TC (OR=3.777; P=0.001) and CC (OR=7.094; P=0.001) genotypes and C (OR=2.605; P=0.001) allele of miR-34b/c rs4938723 are associated with BC recurrence. Conclusion: Thus, miR-34b/c rs4938723 polymorphism is associated with the susceptibility of BC recurrence.

Breast Cancer Recurrence, miR-34b/c, Polymorphism, micro RNA