Mohammad Mokhtari - Department of biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran
Seyed-Morteza Javadirad - Department of biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran

Lung cancer is known as one of the most common cancers around the world and is one of the main causes of cancer mortality. Histologically, lung cancer is divided into Small Cell Lung Cancer (SCLC) and Non-Small Cell Lung Cancer (NSCLC) respectively account for 20 and 80 percent of all lung cancers. One involving gene in NSCLC pathology is thyroid transcription factor-1 (TTF-1) or NK2 Homeobox 2-1 (NKX2-1) which is a homeobox-containing transcription factor. Recently, researchers have found out that micro RNAs may have regulatory effects on this gene. In addition, an increased level of NKX2-1 protein has been observed in NSCLC patients. Therefore, in this study the differences in new regulatory micro RNAs against NKX2-1 gene would be analyzed in the tissues of NSCLC patients and it would be compared to control individuals. Accordingly, the expression levels of target miRNAs would be determined using qPCR with specific primers. Laboratory investigations of this study is to be done and hopefully, the results can be a great help in detection and treatment of patients suffering this catastrophic disease, as well as base for future researches.

Lung Cancer, NSLC، Micro RNA، Real-Time PCR