Mahsa Nasr -Esfahani - Recurrent Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Department of Biology, payame noor university, Taft, Yazd, Iran
Fateme Montazeri - Recurrent Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.. Department of Biology, Yazd university of Science and Art, Yazd, Iran
Fateme Daneshmand - Department of Biology, payame noor university, Taft, Yazd, Iran
Seyed Mehdi Kalantar - Recurrent Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mahya Rajabi - Recurrent Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.. Department of Biology, Yazd university of Science and Art, Yazd, Iran

Background: Infertility is one of the major psychological, economic and social problems in the human society that involves approximately 15% of couples in childbearing years. Although the role of male infertility factors has declined in recent years, but still a major part of infertility is related to the defects of the semen. since nowadays intra cytoplasmic sperm injection (ICSI) is frequently recommended, it is essential to inform them about risk of aneuploidy in their embryo. Objective: To investigate the prevalence of sperm autosome and sex chromosome aneuploeidy in oligoteratospermia (OT) and normozoospermia.Material and Methods: The study include 10 infertile oligoteratospermic men in test and 10 fertile normozoospermic men in control group. We used multi-color FISH probes for chromosomes 13,18,21, X and Y based on the frequency of them in the most reported aneuploidies. moreover, we used standard scoring criteria and a min of 30 sperm for each case to evaluating chromosomal aneuploidies.Result and Conclusion: The overall aneuploidies both in autosome and sex chromosome was higher in OT than the one detected in normozoospermia group (p<0.05). the molecular cytogenetic analysis allows the assessment of sperm aneuploidy rate and increased risk for reproduction failure. Therefore, make it possible an informed counseling for patients and in this regard, preimplantation and prenatal genetic diagnosis/screening are available.

Male infertility, Oligoteratospermia (OT), FISH, Aneuploidy