Ramesh Baradaran Bagheri - عضو هیات علمی دانشگاه البرز
Maryam Eftekhar - عضو هیات علمی دانشگاه یزد
Robabe Hosseinisadat - عضوهیات علمی دانشگاه کرمان
Nosrat Neghab - فلوشیپ ناباروری اهواز

Background and Aim : This study aimed to evaluate the effect of three days of GnRH antagonistpretreatment on the preg- nancy outcomes of women with polycystic ovarian syn- drome (PCOS) on GnRHantagonist protocols for IVF/ICSI.Methods : Fifty women with PCOS in the control group received conventional antagonist protocols,starting on day 2 of the cycle. In the pretreatment group (n=38), a GnRH antagonist was administered fromday 2 of the menstrual cycle for three days.Results : Controlled ovarian stimulation (COS) duration and gonadotropin dosages were similar in bothgroups. The number of metaphase II (MII) oocytes, 2PN oocytes, embryos, along with implantation andclinical pregnancy rates, were higher in the pretreatment group when com- pared with controls, althoughthe increment was not sig- nificant (p value ≥0.05). The chemical pregnancy rate was significantly higherin the pretreatment group. The rate of OHSS was significantly lower in the pretreatment than in the controlgroup.Conclusion : Women with PCOS offered early follicular phase GnRH antagonist pretreatment for threeconsecu- tive days had significantly fewer cases of OHSS and higher chemical pregnancy rates. There weretrends toward great- er numbers of MII oocytes, 2PN oocytes, and embryos, and higher clinical pregnancyrates in the pretreatment group.

assisted reproductive technology, gonado- tropins, polycystic ovarian syndrome