Ali Doostmohammadi - Biomaterials Group, Materials Engineering Department Isfahan University of Technology (IUT) Isfahan, Iran
Ahmad Monshi - Biomaterials Group, Materials Engineering Department Isfahan University of Technology (IUT) Isfahan, Iran
Rasoul Salehi - Department of Genetics and Molecular Biology, School of Medicine Isfahan University of Medical ScienceIsfahan, Iran
Saeid Karbasi - Biomedical Engineering Department, School of Medicine Isfahan University of Medical ScienceIsfahan, Iran

This study aimed at the biocompatibility evaluation of bioglass nanoparticles to chondrocyte cells using isothermal micro/nano calorimetry (IMNC), which is a new method to study cell/biomaterial interactions. For this purpose, 63S bioglass nanoparticles were made via sol-gel method and primary characterization was carried out on the particles. XRD analysis showed the amorphous structure of the glass and the particle size and morphology were investigated by SEM. Finally the bioglass nanoparticles’ biocompatibility with yeast and cultured humanchondrocyte cells was evaluated using IMNC. The results showed no deleterious effect on chondrocyte growth and they can grow, proliferate and live on beside bioglass nanoparticles. In another word, the obtained results from this study confirmed the growth, proliferation and viability of chondrocyte cells close to 63S bioactive glass nanoparticles at low concentrations.

biocompatibility; bioglass; chondrocyte cells;microcalorimetry