Shahab Alizadeh - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Background and Aim: glucose, insulin production, and inflammatory markers in streptozotocin-induced diabetic rats.Methods: Our data showed that the final fasting serum glucose level was significantly lower in the M2000-treated group compared to the diabetic control group (p<.05). In addition, the final fasting serum insulin level significantly increased in the M2000-treated group compared to the diabetic control group (p<.05). Our finding revealed that the serum level of hs-CRP and IL-6 decreased significantly in the M2000-treated group compared to the diabetic control group (p<.05). This study showed that M2000, as a new NSAID, was able to decrease serum glucose levels and increase serum insulin levels and this drug could significantly decrease the inflammatory markers in the M2000-treated group.Conclusion: Collectively, treatment with M2000 might be recommended reducing the severity of diabetes-induced inflammatory symptoms.

M2000; NSAID; blood glucose; insulin; inflammatory markers