Hosein Moharamzadeh - Tabriz university of medical sciences
Saeid Ghorbian - Department of Molecular Biology, Ahar Branch, Islamic Azad University, Ahar, Iran
Ali Dastranj Tabrizi - Pathology Laboratory, Alzahra Hospital, South Artesh Aven., Tabriz, Iran

Introduction: Human trans-activation response (TAR) RNA binding protein 2 (TRBP2), a known molecular partner of the miRNA processing enzyme Dicer, which involved in RNA interference and microRNA pathways. Aberrant expression of TRBP2 is reported in several human cancers. Our aim was to assess the prognostic role of TRBP2 in ovarian cancer patients.Methods: TARBP2 mRNA expression levels were analyzed in 41 specimens, including 17high grade carcinoma and 13 normal ovarian tissue (from healthy woman) by quantitative real-time reverse transcriptase polymerase chain reaction.Results: The results of the study showed that there was no significant difference in the TARBP2 expression levels between normal ovarian tissue and tumoral tissue and also between different of tumoral grades (P > 0.05).Conclusions: In this study, the correlation between TRBP2 gene expression were not detected in ovarian cancer. Our findings suggest that TRBP2 is not an important prognostic marker in ovarian cancer and further investigation of other genes involved in this pathway is recommended.

TRBP2, ovarian cancer, microRNA, Gene Expression, Grade